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Extensive characterisation of T cell, B cell, monocyte, NK cell, gamma delta T cell populationsFlow cytometry can be used to obtain single cell data on target expression, activation markers, proliferation, survival, signalling molecules and many other cellular readouts. Using fluorophore conjugated-antibodies, multiple immune cell subsets can be analysed, and subset selective impact of test compounds assessed at medium-throughput. Some examples of flow cytometry readouts are listed below.
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Assays may suitable for the detailed characterisation of target impact in diseases such as allergy, arthritis, cancer, diabetes, Crohn’s disease, multiple sclerosis, SLE, and others.